Bromsulphalein excretion in the newborn.

Liver function in newborn infants with special reference to excretion of bromsulphalein.

The theory that neonatal jaundice is produced mainly by haemolysis of excess red cells present at birth has been strongly criticized in recent years (Weech, 1947; Findlay, 1946) and increasing emphasis has been placed on the role of the liver in the genesis of this form of jaundice (Weech; Findlay; Mollison, 1948). Direct evidence that the liver in newborn infants is unable to function adequate...

Effect of age on liver function with particular reference to bromsulphalein excretion.

Little is known about the effect of age on liver function. The only study to date is that of Rafsky and Newman (1943) who found increased retention of bromsulphalein in 16 of 39 normal subjects over the age of 70 years compared with a group of 11 subjects aged 60 to 70 years. Liver weight is known, however, to decrease with age. Boyd (1933) analysed 9,886 necropsies and found that the decrease,...

Exercise Electrocardiogram in Myxoedema

An unexpectedly high incidence of abnormalities in the sulphobromophthalein (Bromsulphalein) excretion test, and to a smaller extent in other tests of liver function, was found in patients taking allopurinol and in those on uricosuric treatment. The reason for this is not apparent, but there is no evidence that either type of drug treatment was responsible. It is as yet uncertain whether allopu...

A case of hereditary elliptocytosis associated with constitutional indocyanine green excretory defect.

A 24-year-old woman was diagnosed as having hereditary elliptocytosis and post-transfusion hepatitis. On admission, a marked delay in indocyanine green (ICG) plasma clearance was noted while bromsulphalein excretion was almost normal. Even when her levels of serum bilirubin and transaminases were decreased to the normal ranges and a liver biopsy revealed no evidence of any liver cirrhosis or ac...

Studies of Sulfobromophthalein Sodium (bsp) Metabolism in Man. 3. Demonstration of a Transport Maximum (tm) for Biliary Excretion of Bsp.